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10.1177/014860719902300515 Buchman AL: Glutamine: is it a conditionally required nutrient for the human gastrointestinal system

2.2 Aging and the endocrine system Aging is characterized by changes in all biological systems, and the endocrine system is not an exception

Chronic antigen stimulation and persistent TCR signaling upregulate death receptors such as Fas (CD95) and tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors on activated T cells, increasing their susceptibility to activation-induced cell death (AICD) [304]

This allows the body to burn more fat at equivalent exercise intensity
