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G-CSF receptor-associated Janus kinase 1/2 (JAK1/2) rapidly activate the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) signaling pathways 39,99 and phosphorylate signal transducer and activator of transcription family member 3 (STAT3), causing them to translocate into the nucleus to facilitate the transcription of target genes
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