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For example, exogenous administration of IL6 in healthy humans in the evening was associated with both fatigue and a sleep disturbing effect in the first half of the night, most likely due to increased secretion of corticotrophinreleasing hormone, ACTH, and cortisol, during the early part of the night, induced by IL6 (144)

Corticosteroids suppress inflammation effectively but don't address underlying tissue damage and can degrade cartilage over repeated use

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If you need help understanding your options, speak with your benefits administrator and healthcare provider