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The disc is loaded with compression or shear/distraction, and nucleus pulposus tissue is lost as it herniates either through the ruptured annulus or failed annulus-endplate interface (disc injury type B1) or through the fractures lines of the endplate (disc injury type B3)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 322.Emanuelli T, Burgeiro A, Carvalho E

Across multiple organ systems and injury models, BPC-157 showed cytoprotective effects and no measurable toxicity, even with high cumulative exposure. Sikiric, P