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The fragment works best when administered in a fasted state, as insulin can blunt its lipolytic activity

Ruf S, Rajagopal S, Kadnur SV, Hallur MS, Rani S, Kristam R, Swaminathan S, Zope BR, Gondrala PK, Swamy I (2022) Novel tricyclic small molecule inhibitors of Nicotinamide N -methyltransferase for the treatment of metabolic disorders

More acidic or alkaline conditions may affect peptide stability or cause irritation

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