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Therefore, there is a direct role of oxidative stress through activation of TRPV1 on hyperalgesia in DRG neuron of wild type and Nox1 deficient mice (Ibi et al., 1)

Fluorescence was detected by CLSM

However, given the typically lower abundance of these alkaloids compared with other well studied alkaloids in kratom products, the induction potential of kratom remains uncertain

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