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Loss of BRCA1 function caused by BRCA1 mutation results in the production of hydrogen peroxide in both epithelial breast tumor cells and adjacent stromal fibroblasts, which is able to promote the onset of a reactive glycolytic stroma, suggesting the metabolic phenotype of stromal cells in the TME may also be affected by BRCA1 mutation in tumor cells (225)

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As men grow older, testosterone levels decline gradually with free testosterone concentrations falling by about 50% between ages 25 and 75 years

This isn't surface-level - it's happening in the dermis, the deeper layer where structural proteins live