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Therefore, although both nonenzymatic and enzymatic succinylations occur on GCLC, the latter mediated by P300, in cooperation with SIRT2, may play a major role in dynamically modulating the succinylation level of GCLC under stress condition

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3 using antioxidants to suppress FA cytotoxicity

Expression levels of canonical NOTCH1 target genes, such as NRARP and DTX1 further confirmed these findings, with EDTA used as positive control to induce ligand-independent NOTCH1 activation (Fig
