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Another area of increasing interest is the signaling role of astrocytic lactate beyond its role as an energy substrate: emerging evidence demonstrates that lactate induces histone lysine lactylation (e.g., H3K18la), activating transcription factors like Klf4 to regulate genes associated with synaptic plasticity (e.g., Arc, CREB), thereby contributing to epigenetic remodeling during long-term memory formationa mechanism that underscores metabolic signaling as a target for cognitive enhancement (Yao et al., 2023)

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Tsatsakis A

The Absence of Robust Human Clinical Evidence Despite widespread interest, there is a stark reality: there are no large-scale, randomized controlled human trials evaluating BPC-157 for musculoskeletal or systemic healing