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This triggers broken immune tolerance: Overactivated innate immune cells secrete pro-inflammatory cytokines, CD4 + T cells skew toward pro-inflammatory subsets (T-helper 1 [Th1] cells/Th17), T regulatory cell (Treg) function is impaired, and autoantibodies exacerbate inflammation

Hence, the procognitive activity of a molecule in vivo correlates well with its in vitro ability to alter dendritic spine structure and DSD (Moser et al., 1994

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Studies also confirmed procollegagen synthesis to be increased by almost 70% in dermal fibroblasts