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For the current study, 771 participants with sufficient available sera were selected, including adult-onset diabetes patients positive for RBA-GADA ( n = 278, 51.4% of the Action LADA cohort with RBA-GADA) with or without insulinoma-associated antigen-2 autoantibodies (IA-2A) or zinc transporter-8 autoantibodies (ZnT8A), and patients negative for RBA-GADA ( n = 493) (see Fig

The receptor tetramer can also be composed of both insulin and IGF-I hemireceptor dimers, which are called hybrid receptors