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We identified only two cases of invasive melanoma in male patients in the fifth and sixth decade of life, demonstrating that this neoplasm is very rare in the mouth, particularly amelanotic melanoma
Apelin and its receptor are expressed in human osteoblasts
This case opens the door to still unclear scenarios in which the only weapon available remains the clinicians judgment and experience

In order to obtain better results, some parameters such as the volume and shape of pork samples, the distance between ESI capillary tip and sample edges as well as the distance between sample edges and inlet of mass spectrometry should be kept fixed
