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Nevertheless, the convergence of (i) higher baseline CRP among improvers, (ii) the strong correlation with CRP/NLR and MELD, and (iii) the recognised role of glutathione in modulating redox-sensitive inflammatory pathways, does support a biologically coherent hypothesis: glutathione may be most useful in patients with an inflammatory phenotype, where oxidative stress and systemic inflammation are dominant, modifiable drivers of acute decompensation ( FIGURE 8 The apparent counter-intuitive finding that patients with higher baseline MELD, bilirubin, INR and CRP were more likely to improve also fits this picture
Alam Khan S, Jawaid Akhtar M (2022) Structural modification and strategies for the enhanced doxorubicin drug delivery
PubMed PMID: 34380875 Sikiric et al
10.1016/j.ejca.2015.12.016 Eur
