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The treatment involved 500 mg ALC capsules, with one capsule taken twice daily, or a placebo plus one intramuscular injection of either ALC 500 mg ampoules or placebo for 2 weeks

Importantly, of all the metabolites that significantly distinguished +ADT from ADT group, the only metabolite that significantly correlated with PROMIS-SRI sleep impairment T -scores was androsterone sulfate, which is a metabolic endpoint marker of the effectiveness of ADT in reducing circulating androgens (Chi et al., 2020)

doi: 10.1016/j.breast.2016.02.016 117

Regarding psychological therapies, CBT has shown the most efficacy in the reduction of pain intensity, sleep disturbances, and depression among fibromyalgia patients