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4.1 Summary of key pathophysiological mechanisms UPFs may lead to several pathophysiological changes across several important cellular and biochemical pathways, which have been implicated in the development of psychiatric disorders

Epigenetic Alterations Although a great amount of research has been devoted to the genetic factors that directly affect aging, nongenetic control of aging has gained considerable interest lately as an important aspect in raising awareness of the process of aging

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In contrast to this, SAM may have an opposite role in T cell function by suppressing CD8+ T cell-mediated anti-tumor immunity