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A larger injection volume means more medication concentrated in one area, which inherently triggers a stronger local response
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In contrast, insulin (Mw 5.8 kDa) exhibits limited passive transport into ISF due to its size and dependence on receptor-mediated clearance pathways [37]
Introduction The liver is a major site of metabolism and detoxification of drugs and xenobiotics in the human body ( CYP2E1 ) increases, with an increase in the formation of a highly reactive toxic intermediate metabolite, N-acetyl-p-benzoquinone imine (NAPQI) (Wang et al., 2017)
