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However, when concentrated and added to foods, MSG overstimulates glutamate receptors , contributing to a range of symptoms in sensitive individuals, including: Headaches Brain fog Heart palpitations Anxiety Skin flushing Joint pain While the FDA categorizes MSG as "generally recognized as safe (GRAS)," its widespread use and subtle, cumulative effects raise red flagsespecially for those with neuroinflammatory, immune, or gut-related conditions

However, there is now a substantial literature of genetic association studies of UA-related genes and PD