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Watch for Signs of Copper Toxicity While GHK-Cu is generally well tolerated, overexposure to copper (especially in individuals with impaired detox pathways) can cause symptoms such as: Nausea or gastrointestinal upset Headaches Mood swings or irritability Metallic taste in the mouth If any of these symptoms occur, discontinue use and contact your healthcare provider

Goodfellow MJ, Borcar A, Proctor JL, Greco T, Rosenthal RE, Fiskum G: Transcriptional activation of antioxidant gene expression by Nrf2 protects against mitochondrial dysfunction and neuronal death associated with acute and chronic neurodegeneration

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Garzon R, Liu S, Fabbri M, Liu Z, Heaphy CE, Callegari E, Schwind S, Pang J, Yu J, Muthusamy N, Havelange V, Volinia S, Blum W, Rush LJ, Perrotti D, Andreeff M , Bloomfield CD, Byrd JC, Chan K, Wu LC, Croce CM, Marcucci G