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Optimization of Chromatographic Condition with QbD Concept Analytical target profile (ATP): The objective here is to optimize the chromatographic conditions to improve the quality of the peak in simultaneous estimation, the peaks must be highly resolved with good tailing factor

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To dissect the molecular mechanism, we analyzed the regulatory sequences of CD82 gene and find out that there is a GR binding motif (GGGTACATCCTGTCCCT) in the promoter of CD82 (Fig

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Consistently, the induction of profibrotic genes ( Col1a1, Col3a1, Fn1, Eln, Ccn2, and Acta2 ) and kidney injury markers ( Ngal, Kim-1 ) following UUO was blunted in Usp2 KO mice (Fig

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