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Optimization of Chromatographic Condition with QbD Concept Analytical target profile (ATP): The objective here is to optimize the chromatographic conditions to improve the quality of the peak in simultaneous estimation, the peaks must be highly resolved with good tailing factor

To dissect the molecular mechanism, we analyzed the regulatory sequences of CD82 gene and find out that there is a GR binding motif (GGGTACATCCTGTCCCT) in the promoter of CD82 (Fig

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Consistently, the induction of profibrotic genes ( Col1a1, Col3a1, Fn1, Eln, Ccn2, and Acta2 ) and kidney injury markers ( Ngal, Kim-1 ) following UUO was blunted in Usp2 KO mice (Fig
