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Thiamine deficiency leads to an accumulation of metabolic intermediates, such as pyruvate and lactate, which stabilize HIF-1 through inhibition of prolyl hydroxylases (PHDs), thereby inducing HIF-1-mediated gene expression (49)

References 1 AnH.HarperJ

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It has been suggested in the literature that to adequately address oxidative stress as a contributor to neurodegeneration, that we must also simultaneously address excitotoxicity (Li et al., 2013), but dietary micronutrients may offer an even better solution by reducing all three aspects of the neurotoxic triad, including neuroinflammation