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TnC has a multidomain structure consisting of a coiled-coil region followed by multiple EGF-like domains, fibronectin type-III (FN III) domains, and a fibrinogen C-terminal domain (Okada and Suzuki, 2020)

In addition, berberine is small in size, so it can available through the blood-brain barrier and effectually act on molecular target, showing great therapeutic potential in the treatment of neurodegenerative diseases (Wang et al., 2005

10.1016/j.ab.2020.113833 58 IyamuI

McFarland LV, Huang Y, Wang L, Malfertheiner P (2016) Systematic review and meta-analysis: multi-strain probiotics as adjunct therapy for Helicobacter pylori eradication and prevention of adverse events