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A small number of pilot-scale investigations have been conducted, but large-scale randomized controlled trials have not been published

As esterases are overexpressed in many cancer subtypes utilization of prodrug esters that are activated by the function of esterases into QM to perform GSH depletion is very promising with a number of publications presenting different molecular constructs for prodrug

This observation, coupled with the added stability contributed by C-terminal amidation and the desire to increase the hydrophobicity of the peptide, led to the generation of a series of compounds with the structure N -acyl-Tyr-Ile-(6) amino-hexanoic amide

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