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Contrastingly, functionalisation of the oligonucleotide via a classical NHS-mediated amide coupling (see Supplementary Fig

10.1021/acs.accounts.9b00302 [DOI] [PMC free article] [PubMed] [Google Scholar] Xia CC, Chen HT, Deng H, Huang YT, Xu GQ (2024) Reactive oxygen species and oxidative stress in acute pancreatitis: pathogenesis and new therapeutic interventions

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Notably, both the culture supernatant and bacterial suspension exhibited inhibitory effects, while bacterial protein extracts did not, suggesting that the antimicrobial activity was attributable to metabolic products ( Safety is a fundamental requirement for the practical use of probiotics in animals or humans