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Some patients report feeling tired or low-energy during the first week or two of treatment

Nonetheless, these clinical trials were underpowered to detect rare events such as suicidal ideation and self-injurious behavior, and they systematically excluded patients with psychiatric comorbidities commonly seen in clinical settings

Functional and molecular adaptations of enteroendocrine L-cells in male obese mice are associated with preservation of pancreatic alpha-cell function and prevention of hyperglycemia

In contrast, participants without the risk allele showed correlations in the opposite direction (Karra et al., 2013)