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NF-kb signaling and chronic inflammatory diseases: exploring the potential of natural products to drive new therapeutic opportunities

To study the effects of NO supplementation against the ER stress at molecular levels, we monitored the expression of IRE1, Ero1- L, PDI, and XBP-1, respectively, post-treatment of H660 cells with GSNO at 50 and 100 concentrations

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69 All the above findings based on a few clinical studies with small groups of patients and a few experimental studies remain at present controversial