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The low levels of 2-HG also explained why 2-OGDD activity was preserved following ABHD11 inhibition in CD8 + T cells

A 2025 matched-cohort study found men who started testosterone therapy had significantly higher rates of tendon tears and repairs at one and two years compared to controls, a pattern the authors attributed to testosterone's effect on tendon biomechanics outpacing the tissue's regenerative capacity Sherman et al

Neither form interferes with semaglutide
