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doi: 10.7600/jpfsm.8.147

Notably, ferroptosis induction in cancer cells can trigger immunogenic cell death (ICD), leading to the release of damage-associated molecular patterns that activate dendritic cells and stimulate antitumor T cell responses (110)

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Ample of proteomics and metabolomics studies have proved the considerable lipid metabolism remodeling in the myocardium of AF patients ( 3 AR) ( 2+ -handling and cell contraction, mitochondrial biogenesis, cell growth and proliferation, and so on, thus exerting cardiovascular protection with a combination of multiple mechanisms ( via LCA, a natural and biologically active micronutrient enhancing physiological FAO through CPT1B (Figures 3, 6), can significantly reduce obesity-mediated AF propensity and the corresponding atrial remodeling (Figures 1, 2), thus better supports the efficiency of FAO promotion in the AF therapeutic approach