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Bispecific nanobody activity measured by macrophage phagocytosis Previous studies have demonstrated that PD-L1 antibodies can significantly enhance the proliferation and activation of macrophages in vivo, leading to a proinflammatory phenotype 29,30

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Science 340 , 875879 (2013)

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TB-500 is not FDA approved

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There are two possible reasons for this distinction compared to the published work

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