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Cleanliness and health were afterthoughts In 1960, the Michigan Water Resources Commission gave Flint three years to "abate unlawful pollution of the Flint River." Primary polluters included the factories, paper and packaging companies, the meatpacking industry, various landfills, and the citys wastewater treatment plant

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However, this is less specific than elevated MMA level for vitamin B 12 deficiency, since such elevated homocysteine levels can occur even in vitamin B 6 and folate deficiency states