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[DOI] [PMC free article] [PubMed] [Google Scholar] 108.Macfabe DF
In most of the diseases NAD + was strongly positively associated with NADH and NADP+, which is in line with known role of NAD + as substrate for NADH and NADP+ synthesis
5-Oxoprolinuria can also be caused by mutations in 5-oxoprolinase (OPLAH), a quite rare disease presenting with a high clinical variability

In a model of heart failure established by high methionine diet treatment, plasmatic Hcy level was elevated and an association between HHcy and activation of NF-B was disclosed [98]