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Crocin intervention attenuated CD68, enhanced antioxidant effects by increasing hepatic T-AOC levels and Nrf2 pathway activation as well as Keap1 degradation, enhanced HO-1 expression, reduced the entry of bacterial LPS into the circulation, improved intestinal permeability by increasing the expression of tight junction proteins, which are critical for the function of the epithelial barrier, and alleviated NLRP3 inflammatory vesicles and TLR4 signaling by inhibiting the systemic inflammatory response [142, 143]