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H 2 O 2 level is proportional to the luminescent signal which was measured by a multi-mode microplate reader (FLUOstar Omega)

The stimulation of the cell to the starch formation, which indicates the transition to differentiation, is not associated directly with cessation of divisions [18]

Although this result did not completely reproduce our previous research findings ( The lipid profiles of patients with seronegative and seropositive RA were similar, although some lipids showed differential expression

this can be explained by the effect of VCN on the enhanced activity of the antioxidant nuclear transcriptional factor Nrf2 (a transcription factor that regulates cell responses to oxidative stress and protects against oxidant injury) as was observed in the gene expression analysis of the lung tissue, and supported by a previous study demonstrating the effect of VCN on oxidative stress-induced hepatotoxicity in vitro and in vivo by stabilizing the Nrf2 and preventing its proteasomal degradation via inhibiting the binding of Keap1 and Nrf2 83