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The compound plays a critical role in maintaining the redox homeostasis of the cells and in cell cycle regulation, apoptosis, immunological defense, and pathological abnormalities [8]

Conditional mouse models support the role of SLC39A14 (ZIP14) in hyperostosis cranialis interna and in bone homeostasis

[DOI] [PMC free article] [PubMed] [Google Scholar] 69.Kolenda J., Jensen S.S., Aaberg-Jessen C., Christensen K., Andersen C., Brnner N., Kristensen B.W

These findings suggest that the mitochondria-derived metabolite -KG not only influences nuclear DNA and histone methylation but also may regulate aging through intracellular signaling pathways