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The corresponding cutoff points for the liver enzymes were as follows: 100 ng/mL and 98 ng/mL for ALP, 101 ng/mL and 47 ng/mL for GGT, 58 ng/mL and 36 ng/mL for ALT, and 40 ng/mL and 30 ng/mL for AST, in men and women, respectively
Like rapamycin, NaHS also notably downregulated the levels of p-PI3K, p-Akt and mTOR proteins in HCC cells
However, recent studies have shown that BPTES treatment also upregulates programmed cell death 1 ligand 1 (PD-L1) expression, resulting in an immunosuppressive tumor microenvironment (Byun et al., 2020)
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