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Conversely, silencing GSH-synthesising enzymes (GCLC, GSS and GSR) lowered cellular GSH levels (Supplementary Figure S3A and B) and rendered the sensitive PC9 cells erlotinib-resistant (Figure 2c)

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Mechanistically, iron overload in FBXL5-deficient cells increases IL-6 production by facilitating the recruitment of nuclear factor-B to the Il-6 promoter