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BdTyrA) were compared to previously crystallized GmPDH1 (Schenck et al., S6)

Kochman et al., 2026), (ii) enhance interaction with brain endothelial cells and overcome the BBB for systemic delivery pathway (Guo et al., 2020), while circumvent the mucociliary clearance and enhance nasal permeability for nose-to-brain delivery pathway (Sood et al., 2014

Enzyme activity was barely affected at 1050 C, indicating that the protein structure was stable within this temperature range

It is well recognized that proteins are highly susceptible to oxidative damage that inevitably affects secondary and tertiary structure, resulting in irreversible modification of protein shape and, consequently, function