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The loss of the sod-A gene in mutant bacteria harms the ability to infect the host cell

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NO is an active molecule produced by the nitric oxide synthase (NOS) protein family, which directly binds and inactivates iron-containing enzymes [48] or reacts with superoxide anion radical O2 to form a highly active peroxy sulfoxide Nitrates (ooo-), which can attack membrane lipids and proteins of the pathogens, especially protein thiols [49]

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[DOI] [PubMed] [Google Scholar] 2.Darwish Murad S, Dom VA, Ritman EL, de Groen PC, Beigley PE, Abraham SC, Zondervan PE, Janssen HL

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Naunyn Schmiedebergs Arch Pharmacol 391:12471255 Shalkami A-GS, Hassanein EH, Sayed AM, Mohamed WR, Khalaf MM, Hemeida RA (2021) Hepatoprotective effects of phytochemicals berberine and umbelliferone against methotrexate-induced hepatic intoxication: experimental studies and in silico evidence

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