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MOTS-c disc research: The direct evidence of MOTS-c preserving disc height and reducing degeneration in animal models positions it as one of the most promising candidates for future clinical development specifically targeting disc disease

The copper component serves as an essential cofactor for lysyl oxidase and lysyl hydroxylase, enzymes critical for proper collagen cross-linking

Stress: Chronic stress and elevated cortisol can interfere with growth hormone signaling

doi:10.1371/journal.pone.0121880 Bian Y, He X, Hu S, et al
