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Butyrate promotes mitochondrial hyperfusion (via upregulating fusion proteins Opa1/Mfn2 and downregulating fission protein Fis1), enhances glucose-stimulated oxygen consumption and mitochondrial membrane potential, and restores redox homeostasis by increasing reduced glutathione (GSH) levels and the GSH/GSSG ratio

Other Factors: Certain genetic factors, such as mutations in genes involved in vitamin B12 metabolism, can predispose individuals to vitamin B12 deficiency

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Autophagy is a phagocytic degradation process whose deregulation may contribute to neuronal cell death and is involved in the mechanisms of pathologic conditions, such as cerebral ischemia (Sun et al., 2019)