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ApoE serves as the ligand for hepatic clearance of ApoB-containing lipoproteins, especially chylomicron, from the blood except for LDL via interacting with ApoE receptors including the LRP1 and the VLDL receptor, which are not regulated by cellular cholesterol (Marais, 2019)

CrossRef The Effectiveness of Mobile Phone-Based Care for Weight Control in Metabolic Syndrome Patients: Randomized Controlled Trial Bumjo Oh, Belong Cho, Min Kyu Han, Hochun Choi, Mi Na Lee, Hee-Cheol Kang, Chang Hee Lee, Heeseong Yun, Youngho Kim JMIR mHealth and uHealth.2015

Moreover, it is not known whether LCACs indirectly affect ion channel or enzyme function via incorporation into local lipid domains, which could induce a conformational change in the integral membrane proteins