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An Arabidopsis thaliana acetyltransferase, NATA1, has been shown to have important regulatory functions on plant polyamines

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Large animal models regarding AD are mainly constructed surgically and can be used for the study of disease progression and treatment modalities, but they are technically demanding, can only study surgically induce traumatic entrapment, are unsuitable for the study of AD pathogenesis, and are not as reproducible as small animal models (71, 72)