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However, despite sustained anti-PD-1/PD-L1 treatment, persistent T-cell dysfunction was observed, indicating that simply blocking these immune checkpoints may not be sufficient for achieving durable tumor regression
Conversion of 5-OP to Glu by 5-Oxoprolinase The 5-OP that is the result of CHAC-catalyzed glutathione cleavage is converted to Glu by 5-oxoprolinase (OPLAH) in an ATP-dependent manner [122]
For comparisons between the study groups, we used Student t-test for continuous variables and Fisher exact test for discrete variables, according to the data type
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