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Given the role of GPx1 in promoting cell survival pathways, the effectiveness of other chemotherapeutic agents, such as the isothiocyanate iberin, may be due, in part, to their ability to decrease GPx1 expression

The A3 adenosine receptor agonist CF502 inhibits the PI3K, PKB/Akt and NF-kappaB signaling pathway in synoviocytes from rheumatoid arthritis patients and in adjuvant-induced arthritis rats

In animal models, oral administration, topical application, and/or injection of resveratrol inhibited the development of chemically-induced cancer at many sites, including gastrointestinal tract, liver, skin, breast, prostate, and lung (reviewed in 68, 69)

[DOI] [PMC free article] [PubMed] [Google Scholar] Oja SS, Janaky R, Varga V, Saranasaari P
