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Description
Several GLS inhibitors have been developed, among which CB-839 is currently undergoing clinical trials as a potent, orally bioavailable GLS-selective inhibitor for the treatment of various cancers, including TNBC, NSCLC, and colon cancer (NCT03057600, NCT03057600, NCT03057600, NCT03057600, NCT03057600, NCT03057600)
519,520 Kwon et al
The enzyme glutaminase (GLS) converts glutamine into glutamate, allowing it to enter the TCA cycle and support other important growth pathways
10.1626/pps.13.164 152 YeX
