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doi: 10.1007/s00401-018-1932-x, 94 MuckenthalerM

Formation of the Schiff base leads to dehydration of the intermediate

AOD-9604 offers a gentler approach with more selective fat targeting and fewer systemic effects, making it suitable for individuals who cannot tolerate GLP-1 agonists or prefer a more focused mechanism

Taking into the account the dual antioxidant abilities related to the antiproliferative and pro-oxidant abilities related to the cytotoxic effects of melatonin opens the door to novel indication of the indole in different cancer cells
