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While organelles with more flexible membranes may accommodate such crowding, the stiff nucleus is particularly vulnerable: excessive LD accumulation can physically compress and damage nuclear architecture 139,140 , causing nuclear stress and DNA damage on biophysics level

J Intern Med 277:717726
control at 2837 mU/ml 24 h after post-run ( P = 0003)

Ohayon MM, Chen MC, Bixler E, et al
