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Compounds valuable for these efforts were analogues of glutamate that are conformationally constrained by the addition of substituents to the carbon backbone of glutamate or aspartate (b-hydroxyaspartate or methylglutamate derivatives), and the incorporation of ring systems (carboxycyclopropyl)glycines, aminocyclobutane dicarboxylates, or pyrrolidine dicarboxylates

Histone deacetylases including SIRT1, interact with STAT3 and negatively regulate its transcriptional activity by deacetylating critical lysine residues (Nie et al., 2009)

V., Leitner, W