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Description
Glutamate-cysteine ligase (Gcl) is the rate-limiting enzyme in GSH synthesis and condensing glutamine and cysteine into -glutamylcysteine, which is then combined with glycine in a reaction catalyzed by GSH synthase to form GSH 10

Cancer Res 66(16):82938296 Yan H, Zhu Y, Liu B, Wu H, Li Y, Wu X et al (2011) Mitogen-activated protein kinase mediates the apoptosis of highly metastatic human non-small cell lung cancer cells induced by isothiocyanates

New insights into insulin: the anti-inflammatory effect and its clinical relevance

Second, passive diffusion occurs when very high oral doses are consumed
