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J Hematol Oncol

We identified a rare B cell cluster (0.47% of the final dataset) that expressed Cd19 , Cd22 and Ms4a1 (Extended Data Fig

Common effects: Injection-site reactions (mild redness, slight discomfort) most common Transient headaches (resolved without intervention) Mild fatigue in some subjects (usually early in treatment) No serious adverse events reported Laboratory changes: No significant changes in blood glucose or insulin levels No effects on liver enzymes or kidney function No changes in IGF-1 levels (confirming the absence of a GH rise) No clinically significant changes in other laboratory parameters Phase 2 trials (overweight/obese subjects): Efficacy trials in overweight and obese populations confirmed the favorable safety profile

Researchers have proposed that inhibiting NNMT may influence downstream metabolic pathways by altering nicotinamide utilisation and methyl donor availability