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This figure includes expenditures on both obesity-indicated GLP-1s and Type 2 diabetes-indicated GLP-1s prescribed to patients with an obesity diagnosis

Minamata disease revisited: an update on the acute and chronic manifestations of methyl mercury poisoning

24.5 3.5 kg m 2

In terms of the magnitude of fat mass reduction in controlled research settings: Semaglutide (GLP-1 alone): ~1015% body weight Tirzepatide (GLP-1 + GIP): ~1622% body weight Retatrutide (GLP-1 + GIP + Glucagon): ~2429% body weight (Phase 2 data) This stepwise increase with each additional receptor target is a remarkable demonstration of pharmacological synergy and has driven enormous interest in the triple-agonist research space